Inhibition of breast cancer cell proliferation by Annurca apple polyphenols

Apples are among the most consumed fruits worldwide, and several studies suggest that apple polyphenols could play a role in the prevention of degenerative diseases. The present study is aimed at evaluating the effects of Annurca apple polyphenol extract (APE) on proliferation on MCF-7 cells. The data indicated that apple polyphenolic compounds had significant antiproliferative action on MCF-7 cells inducing a cell cycle arrest at G2/M phase. APE was also capable of provoking morphological changes as demonstrated by nuclear condensation. The cellular, morphological, and molecular data suggested that induction of cellular apoptosis was mainly responsible for the observed antiproliferation-induced APE on MCF-7 cells. Taken together all data, it was possible to speculate that APE acts at low micromolar range against breast cancer cells and it may be considered as a promising candidate for anticancer therapy