Transcription factor TBX1 overexpression induces downregulation of proteins involved in retinoic acid metabolism: a comparative proteomic analysis. Caterino M, Ruoppolo M, Fulcoli G, Huynth T, Orrù S, Baldini A, Salvatore F. CEINGE Biotecnologie Avanzate scarl, Napoli, Italy, Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli Federico II, Napoli, Italy. TBX1 haploinsufficiency is considered a major contributor to the del22q11.2/DiGeorge syndrome (DGS) phenotype. We have used proteomic tools to look at all the major proteins involved in the TBX1-mediated pathways in an attempt to better understand the molecular interactions instrumental to its cellular functions. We found more than 90 proteins that could be targeted by TBX1 through different mechanisms. The most interesting observation is that overexpression of TBX1 results in down-regulation of two proteins involved in retinoic acid metabolism.
TRANSCRIPTION FACTOR TBX1 OVEREXPRESSION INDUCES DOWNREGULATION OF PROTEINS INVOLVED IN RETINOIC ACID METABOLISM: A COMPARATIVE PROTEOMIC ANALYSIS
ORRU', STEFANIA;
2009-01-01
Abstract
Transcription factor TBX1 overexpression induces downregulation of proteins involved in retinoic acid metabolism: a comparative proteomic analysis. Caterino M, Ruoppolo M, Fulcoli G, Huynth T, Orrù S, Baldini A, Salvatore F. CEINGE Biotecnologie Avanzate scarl, Napoli, Italy, Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli Federico II, Napoli, Italy. TBX1 haploinsufficiency is considered a major contributor to the del22q11.2/DiGeorge syndrome (DGS) phenotype. We have used proteomic tools to look at all the major proteins involved in the TBX1-mediated pathways in an attempt to better understand the molecular interactions instrumental to its cellular functions. We found more than 90 proteins that could be targeted by TBX1 through different mechanisms. The most interesting observation is that overexpression of TBX1 results in down-regulation of two proteins involved in retinoic acid metabolism.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
