Aging-associated chronic diseases, such as neurodegenerative disorders, have a dramatic impact on healthcare systems. Despite progresses in understanding their etiology, unsolved questions still exist. These complex disorders share a common inflammatory status and are influenced by common post-transcriptional mechanisms of gene regulation. MicroRNAs, key players in modulating gene expression, and other non-coding RNAs have specific spatial-temporal expression in the brain, and a critical role in neurogenesis and neurodegenerative diseases. Here, we review the emerging impact of noncoding RNAs in their pathogenesis, also performing a computational analysis on microRNAs and target genes. Our findings strengthen the notion of an inflammatoryrelated component in neurodegenerative disorders, confirming the contribution of microRNA-dependent gene expression regulation in the etiology of such diseases.
Non-coding RNA in Neurodegeneration
Ciccodicola A;
2012-01-01
Abstract
Aging-associated chronic diseases, such as neurodegenerative disorders, have a dramatic impact on healthcare systems. Despite progresses in understanding their etiology, unsolved questions still exist. These complex disorders share a common inflammatory status and are influenced by common post-transcriptional mechanisms of gene regulation. MicroRNAs, key players in modulating gene expression, and other non-coding RNAs have specific spatial-temporal expression in the brain, and a critical role in neurogenesis and neurodegenerative diseases. Here, we review the emerging impact of noncoding RNAs in their pathogenesis, also performing a computational analysis on microRNAs and target genes. Our findings strengthen the notion of an inflammatoryrelated component in neurodegenerative disorders, confirming the contribution of microRNA-dependent gene expression regulation in the etiology of such diseases.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
