Aerosols from eight e-cigarettes at different nicotine levels and flavoring were characterized as particle number size distributions in the range 5.6-560 nm by FMPS and CPC. Results were used to provide dosimetry estimates applying the MMPD model. Particle number concentrations varied between 3.26 Ã 10<sup>9</sup> and 4.09 Ã 10<sup>9</sup> part cm<sup>-3</sup> for e-liquids without nicotine and between 5.08 Ã 10<sup>9</sup> and 5.29 Ã 10<sup>9</sup> part cm<sup>-3</sup> for e-liquids with nicotine. No flavor effects were detected on particle concentration data. Particle size distributions were unimodal with modes between 107-165 nm and 165-255 nm, for number and volume metrics, respectively. Averagely, 6.25 Ã 10<sup>10</sup> particles were deposited in respiratory tree after a single puff. Highest deposition densities and mean layer thickness of e-cigarette liquid on the lung epithelium were estimated at lobar bronchi. Our study shows that e-cigarette aerosol is source of high particle dose in respiratory system, from 23% to 35% of the daily dose of a no-smoking individual.
|Titolo:||Aerosol deposition doses in the human respiratory tree of electronic cigarette smokers|
|Data di pubblicazione:||2015|
|Appare nelle tipologie:||1.1 Articolo in rivista|