Objective: To investigate the relationship between cognitive deficits, Impulse Control Disorders (ICDs) and Punding in Parkinson’s disease (PD). Background: The neuropsychological correlates of ICDs and punding in non-demented patients with PD are unclear. Some studies revealed an association between deficits of specific cognitive functions (i.e. setshifting, spatial planning) in PD patients with ICDs, while other studies did not find any relationship. Only one study investigated cognitive correlates of punding in PD revealing an association between the two constructs. Methods: We enrolled 28 patients with ICD and punding (ICDs+P), 17 patients with ICDs without punding (ICDs-P) and 31 patients without ICDs and punding (PD). They underwent Parkinson’s disease Cognitive Rating Scale (PDCRS), cognitive tasks to evaluate global cognition, memory, executive functions (i.e. spatial planning, selective attention, set-shifting, inhibitory control, phonological fluency), visual-perceptive abilities. Results: The three groups did not differ on clinical and demographic variables. The performance of the three groups differed on tasks assessing global cognition, verbal delayed recall, spatial planning, frontal/executive functions and on PDCRS. In detail, the ICDs+P group performed poorly than PD group on tasks assessing delayed recall, spatial planning, selective attention, set-shifting, inhibitory control, phonological fluency. Moreover, the ICDs-P group performed worse than PD group on PDCRS and task assessing set-shifting and inhibitory control. No significant difference was found between patients with and without punding with regard to both clinical and neuropsychological findings. Conclusions: Our findings revealed that occurrence of ICDs and Punding in PD is related to alteration of both frontal-striatal circuitries and posterior cortical areas. Moreover, our results suggested that ICDs, Punding, and cognitive defects might be the epiphenomena of common altered neural substrates
Neuropsychological correlates of impulse control disorders and punding in Parkinson´ s disease
VITALE, Carmine
2016-01-01
Abstract
Objective: To investigate the relationship between cognitive deficits, Impulse Control Disorders (ICDs) and Punding in Parkinson’s disease (PD). Background: The neuropsychological correlates of ICDs and punding in non-demented patients with PD are unclear. Some studies revealed an association between deficits of specific cognitive functions (i.e. setshifting, spatial planning) in PD patients with ICDs, while other studies did not find any relationship. Only one study investigated cognitive correlates of punding in PD revealing an association between the two constructs. Methods: We enrolled 28 patients with ICD and punding (ICDs+P), 17 patients with ICDs without punding (ICDs-P) and 31 patients without ICDs and punding (PD). They underwent Parkinson’s disease Cognitive Rating Scale (PDCRS), cognitive tasks to evaluate global cognition, memory, executive functions (i.e. spatial planning, selective attention, set-shifting, inhibitory control, phonological fluency), visual-perceptive abilities. Results: The three groups did not differ on clinical and demographic variables. The performance of the three groups differed on tasks assessing global cognition, verbal delayed recall, spatial planning, frontal/executive functions and on PDCRS. In detail, the ICDs+P group performed poorly than PD group on tasks assessing delayed recall, spatial planning, selective attention, set-shifting, inhibitory control, phonological fluency. Moreover, the ICDs-P group performed worse than PD group on PDCRS and task assessing set-shifting and inhibitory control. No significant difference was found between patients with and without punding with regard to both clinical and neuropsychological findings. Conclusions: Our findings revealed that occurrence of ICDs and Punding in PD is related to alteration of both frontal-striatal circuitries and posterior cortical areas. Moreover, our results suggested that ICDs, Punding, and cognitive defects might be the epiphenomena of common altered neural substratesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
