This work focuses on a University-based Spin Off (USO) with consequent review of the traditional university mission on the need/opportunity to give more to Knowledge. Europe, Italian government and other institutions fund spinoffs through announcements, in which the evaluation method for merits still shows limitations, due to a light presence of Italian excellence. The work, starting from the Service Science Management Engineering and Design (SSMD+D), proposes a review of the literature about demographic factors in the founding team, but more generally of human capital in spin-offs in order to create value. According to Visintin and Pittino (see [23]), the paper aims to design a kernel of a fuzzy logic based DSS to evaluate ex-ante the likely success of the founding team of a USO. Academic spin – offs of the University of Salerno are useful to test the DSS.