The decisions taken with respect to the determinants of sustainability, that is, with respect to growth, new paradigms of well-being and global socio-economic and demographic trends, represent the nerve center of any strategy for growth and maintenance in time and space of economic, social, environmental, territorial and generational well-being. With this in mind, this paper, having identified the principle of responsibility as a genetic factor of sustainability of the well-being highlights how the decisions taken, through a multi-level and multi-trajectories approach, they must necessarily be based on this principle in ensuring in this way, that in time and space the stock of natural, human, economic and social capital will be repeatable.